Introductory statement: proceedings of Conference on Public Health Implications of Components of Plastic Manufacture.

نویسنده

  • E. Gallina
چکیده

In patients with advanced head and neck squamous cell carcinoma (HNSC), evidence of cellmediated immunity and monocyte functional abnormalities has been reported. We studied the production of interleukin 1 beta (IL-lbeta) and interleukin 6 (IL-6) by peripheral blood monocytes from 22 patients with HNSC (12 larynx and ten oral cavity cancers) in comparison with monocyte cytokine production of age-matched healthy subjects. Pure monocytes were incubated with and without lipopolysaccarides (LPS) (10 1tg ml-') for 4 h at 37C and IL-Ibeta and IL-6 concentrations were determined in supernatants by specific ELISA. There was no significant difference in IL1beta levels in monocyte supernatants from cancer in comparison to control subjects; conversely, a higher IL-6 production by unstimulated and LPS-activated cells from HNSC patients than from controls was found. No relationship was observed between cytokine production and cancer stage. The regression analysis evidenced a significant correlation between IL-lbeta and IL-6 monocyte-release in HNSC patients and in controls, so suggesting a possible autocrine control of IL-6 production by other cytokines.

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Proceedings of the WHO-NIEHS conference on potential environmental health hazards from technological developments in rubber and plastics industries. Research Triangle Park, N.C., March 1-3, 1976: Introductory statement.

It is a pleasure for me to welcome, on behalf of Dr. Mahler, Director-General of the World Health Organization, the participants in this Symposium on Potential Health Hazards from Technological Developments in the Rubber and Plastics Industries. At the same time, I should like to convey to the Government of the United States Dr. Mahler's appreciation of the generous support provided for this jo...

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عنوان ژورنال:
  • Environmental Health Perspectives

دوره 11  شماره 

صفحات  -

تاریخ انتشار 1975